RUNX Proteins in Development and Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Groner, Yoram (Επιμελητής έκδοσης), Ito, Yoshiaki (Επιμελητής έκδοσης), Liu, Paul (Επιμελητής έκδοσης), Neil, James C. (Επιμελητής έκδοσης), Speck, Nancy A. (Επιμελητής έκδοσης), van Wijnen, Andre (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2017.
• Σειρά: Advances in Experimental Medicine and Biology, 962
• Θέματα: Medicine.; Medical genetics.; Oncology.; Proteins.; Biomedicine.; Gene Function.; Protein Science.

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. Howe...

Πίνακας περιεχομένων:

• RUNX in invertebrates
• Structure and biophysics of CBFb/RUNX and its transcription products
• Covalent modification of RUNX proteins: structure affects function
• The role of Runx1 in embryonic blood cell formation
• RUNX1 structure and function in blood cell development
• Roles of Runx2 in skeletal development
• Roles of Runx genes in nervous system development
• Runx family genes in tissue stem cell dynamics
• Roles of RUNX1 enhancer in normal hematopoiesis and leukemogenesis
• RUNX1-ETO leukemia
• Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders
• Mechanism of ETV6-RUNX1 leukemia
• ETV6-RUNX1+ acute lymphoblastic leukemia in identical twins
• Molecular basis and targeted inhibition of CBFb-SMMHC acute myeloid leukemia
• The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models
• RUNX1 and CBFb mutations and activities of their wild-type alleles in AML
• Roles of RUNX in B cell immortalization
• Roles of RUNX in solid tumors
• RUNX3 and p53: How two tumor suppressors cooperate against oncogenic Ras
• Runx3 and cell fate decisions in pancreas cancer
• RUNX genes in breast cancer and the mammary lineage
• Runx3 in immunity, inflammation and cancer
• Roles of RUNX complexes in immune cell development
• CBFb and HIV infection
• Roles of RUNX in Hippo pathway signaling
• Roles of RUNX in hypoxia-induced responses and angiogenesis
• The emerging roles of RUNX transcription factors in Epithelial-Mesenchymal Transition
• Regulatory role of RUNX1 and RUNX3 in the maintenance of genomic integrity.