Cellular Osmolytes From Chaperoning Protein Folding to Clinical Perspectives /

This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environme...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Rajendrakumar Singh, Laishram (Επιμελητής έκδοσης), Dar, Tanveer Ali (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2017.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 1 0 |a Cellular Osmolytes  |h [electronic resource] :  |b From Chaperoning Protein Folding to Clinical Perspectives /  |c edited by Laishram Rajendrakumar Singh, Tanveer Ali Dar. 
264 1 |a Singapore :  |b Springer Singapore :  |b Imprint: Springer,  |c 2017. 
300 |a VII, 249 p. 36 illus., 16 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Polyols as exceptional Protein stabilizers -- Osmolyte mixtures versus individuals in protein folding and aggregation -- Molecular insights of Osmolyte-protein Interaction -- MDS simulation studies on osmolyte protein interactions -- Osmolytes as protein aggregation Modifiers -- Osmolytes as Nano-probes of conformational changes -- Inhibition of Protein fibrillation by Chemical chaperones: a Therapeutic strategy -- Osmolyte in Infectious Diseases -- Possible strategies for the therapeutic intervention of osmolyte in Cancer -- Antioxidant osmolytes -- Advances on the in vivo studies of the effect of osmolyte on various pathophysiological conditions -- TMAO in alpha Synuclein aggregation -- Osmolytes: from cell physiology to Disease Prevention -- Osmolytes in Cell-volume Regulation -- Role of Osmolytes in counteracting the deleterious effects of denaturant/pressure. 
520 |a This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding. Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure. 
650 0 |a Medicine. 
650 0 |a Cancer research. 
650 0 |a Biomedical engineering. 
650 0 |a Biochemistry. 
650 0 |a Plant biochemistry. 
650 0 |a Proteins. 
650 0 |a Cell physiology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Biomedical Engineering/Biotechnology. 
650 2 4 |a Cell Physiology. 
650 2 4 |a Protein-Ligand Interactions. 
650 2 4 |a Cancer Research. 
650 2 4 |a Animal Biochemistry. 
650 2 4 |a Plant Biochemistry. 
700 1 |a Rajendrakumar Singh, Laishram.  |e editor. 
700 1 |a Dar, Tanveer Ali.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9789811037061 
856 4 0 |u http://dx.doi.org/10.1007/978-981-10-3707-8  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)