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03172nam a22005415i 4500 |
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978-981-10-4310-9 |
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DE-He213 |
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170621s2017 si | s |||| 0|eng d |
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|a 9789811043109
|9 978-981-10-4310-9
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|a 10.1007/978-981-10-4310-9
|2 doi
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|a MED107000
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|a SCI029000
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|a 611.01816
|2 23
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|a RNA Activation
|h [electronic resource] /
|c edited by Long-Cheng Li.
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|a Singapore :
|b Springer Singapore :
|b Imprint: Springer,
|c 2017.
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| 300 |
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|a XIV, 239 p. 45 illus., 38 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 983
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|a PART I Exogenous RNAa -- PART II Endogenous RNAa -- PART III RNA activation guided by other small RNAs -- PART IV Developing RNAa-based therapeutics -- .
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| 520 |
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|a This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs). With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development. .
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|a Medicine.
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|a Cancer research.
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| 650 |
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|a Gene expression.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Biochemistry.
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|a Cell biology.
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|a Biomedicine.
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| 650 |
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|a Gene Expression.
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|a Biochemistry, general.
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| 650 |
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|a Cell Biology.
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| 650 |
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|a Molecular Medicine.
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| 650 |
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|a Cancer Research.
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| 700 |
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|a Li, Long-Cheng.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9789811043093
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 983
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-981-10-4310-9
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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