Development of a Fully Integrated "Sample-In-Answer-Out" System for Automatic Genetic Analysis

• Main Author: Zhuang, Bin (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Biomedical engineering.; Genetic engineering.; Nucleic acids.; Biomedical Engineering and Bioengineering.; Genetic Engineering.; Nucleic Acid Chemistry.

This thesis reports on the development of a fully integrated and automated microsystem consisting of low-cost, disposable plastic chips for DNA extraction and PCR amplification, combined with a reusable glass capillary array electrophoresis chip, which can be employed in a modular-based format for g...

Table of Contents:

• Introduction
• The construction of a general platform for capillary electrophoresis
• Integrated module for automatic DNA extraction and amplification
• A fully-integrated genetic analysis system
• Conclusion and prospects for future work.