Developmental Origins of Health and Disease (DOHaD) From Biological Basis to Clinical Significance /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kubota, Takeo (Editor, http://id.loc.gov/vocabulary/relators/edt), Fukuoka, Hideoki (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Advances in Experimental Medicine and Biology, 1012
• Subjects: Human physiology.; Reproductive medicine.; Developmental biology.; Human Physiology.; Reproductive Medicine.; Developmental Biology.

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA,...

Table of Contents:

• Part 1 Biological Basis
• One carbon metabolism and lipid metabolism in DOHaD
• Novel models of epigenetic gene regulation in the nutritional environment
• Epigenetic switching and neonatal nutritional environment
• Part 2 Disease and environment
• Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD)
• Fetal origins of hypertension
• Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory
• Part 3 Transgenerational mechanism and its consequences
• Placental development and nutritional environment
• Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm
• Part 4 Clinical Significance
• Preemptive epigenetic medicine based on fetal programming.