Advancing Development of Synthetic Gene Regulators With the Power of High-Throughput Sequencing in Chemical Biology /

• Main Author: Chandran, Anandhakumar (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Biotechnology.; Gene therapy.; Bioorganic chemistry.; Gene Therapy.; Bioorganic Chemistry.

This book focuses on an "outside the box" notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive go...

Table of Contents:

• Overview of Next-Generation Sequencing Technologies and its application in Chemical Biology
• Next Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specificity by the Addition of β-alanine
• Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by Utilizing the Power of High-Throughput Sequencing
• Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing.