Mitochondrial DNA and Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Sun, Hongzhi (Editor), Wang, Xiangdong (Editor)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2017.
• Series: Advances in Experimental Medicine and Biology, 1038
• Subjects: Life sciences.; Human genetics.; Cell biology.; Life Sciences.; Cell Biology.; Human Genetics.

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the signific...

Table of Contents:

• How far can mitochondrial DNA drive the disease?
• Mitochondrial DNA in lung cancer
• Approach, application and bioethics of mtDNA sequencing in cancer
• Roles of mitochondrial DNA signaling in immune responses
• Mitochondrial DNA in Telocytes
• Roles of mitochondrial DNA in energy metabolism
• The role of base excision repair in maintaining mitochondrial DNA stability.- Is mitochondrial cell fragility a cell weakness?
• Mitochondrial DNA methylation and related disease
• Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis
• Metabolic regulation in mitochondria and drug resistance.- Mitochondrial Lon Protease and Cancer
• Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease.