DNA Replication From Old Principles to New Discoveries /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Masai, Hisao (Επιμελητής έκδοσης), Foiani, Marco (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2017.
• Σειρά: Advances in Experimental Medicine and Biology, 1042
• Θέματα: Life sciences.; Cytogenetics.; Biochemistry.; Cell biology.; Life Sciences.; Cell Biology.; Biochemistry, general.

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historica...

Πίνακας περιεχομένων:

• Preface
• Biography
• Chapter1. Historical Perspective of Eukaryotic DNA Replication
• Chapter2. Regulation of replication origins
• Chapter3. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells
• Chapter4. Initiation of DNA replication at the chromosomal origin of E. coli, oriC
• Chapter5. Initiation of DNA replication in the archaea
• Chapter6. Mechanism of lagging strand DNA replication in eukaryotes
• Chapter7. Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication
• Chapter8. Termination of eukaryotic replication forks
• Chapter9. Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex
• Chapter10. Architecture of The Saccharomyces cerevisiae Replisome
• Chapter11. Replication domains: genome compartmentalization into functional replication units
• Chapter12. Rif1-dependent regulation of genome replication in mammals
• Chapter13. G-quadruplexes and DNA replication origins
• Chapter14. Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions
• Chapter15. Chromatin replication and histone dynamics
• Chapter16. The temporal regulation of S phase proteins during G1
• Chapter17. Roles of SUMO in replication initiation, progression, and termination
• Chapter18. The multiple roles of ubiquitylation in regulating challenged DNA replication
• Chapter19. Regulation of mammalian DNA replication via the ubiquitin-proteasome system
• Chapter20. Coordinating replication with transcription
• Chapter21. Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites
• Chapter22. Cyclin E deregulation and genomic instability
• Chapter23. Replication through repetitive DNA elements and their role in human diseases.