Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

• Κύριος συγγραφέας: Wong, Daniel Yuan Qiang (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Medicinal chemistry.; Medical biochemistry.; Cancer research.; Medicinal Chemistry.; Medical Biochemistry.; Cancer Research.

This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a ric...

Πίνακας περιεχομένων:

• Introduction- Cisplatin- Now and Future
• Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum (IV) Prodrugs
• Probing the Platinum(IV) Prodrug Hypothesis - Are Platinum(IV) Complexes Really Prodrugs of Cisplatin?
• Induction of Targeted Necrosis with HER2-Targeted Platinum(IV) Anticancer Prodrugs
• Immuno-Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents
• Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes
• Concluding Remarks.