Molecular Recognition of DNA Double Helix Gene Regulation and Photochemistry of BrU Substituted DNA /

• Main Author: Saha, Abhijit (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Bioorganic chemistry.; Nucleic acids.; Regenerative medicine.; Tissue engineering.; Bioorganic Chemistry.; Nucleic Acid Chemistry.; Regenerative Medicine/Tissue Engineering.

In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to...

Table of Contents:

• 1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA
• 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity
• 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast
• 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites
• 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay
• 6.UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258. .