Total Synthesis of Natural Products with Antimicrobial Activity

• Κύριος συγγραφέας: Giltrap, Andrew (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Medicinal chemistry.; Medical biochemistry.; Drug resistance.; Medicinal Chemistry.; Medical Biochemistry.; Drug Resistance.

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllam...

Πίνακας περιεχομένων:

• Introduction
• Total Synthesis of Teixobactin
• Synthesis of Deshydroxy Skyllamycins A-C
• Total Synthesis of Skyllamycins A-C
• Experimental.