Development of Antibody-Based Therapeutics Translational Considerations & Challenges /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Tabrizi, Mohammad A. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Bornstein, Gadi G. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Klakamp, Scott L. (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Adis, 2018.
• Έκδοση: 2nd ed. 2018.
• Θέματα: Pharmacy.; Pharmacology.; Biochemistry.; Pharmacology/Toxicology.; Biochemistry, general.

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respec...

Πίνακας περιεχομένων:

• 1. Introduction
• 2. Translational Considerations and Challenges: An Overview
• 3. Considerations for Construct and Affinity Design Goals
• 4. Epitope Characterization and Isotype Selection
• 5. Biophysical Considerations for Development of Antibody-Based Therapeutics
• 6. Novel Technologies for Generation of Bispecific Constructs
• 7. Stimulus-Response Mechanisms: An Overview
• 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models -A Quantitative Approach
• 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities
• 10. Antibody Drug Conjugates: Translational Considerations
• 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs
• 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.