Cancer RNome: Nature & Evolution

• Κύριοι συγγραφείς: Arora, Mansi (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut), Kaul, Deepak (http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Θέματα: Cancer research.; Human genetics.; Molecular biology.; Biomedical engineering.; Laboratory medicine.; Cancer Research.; Human Genetics.; Molecular Medicine.; Biomedical Engineering/Biotechnology.; Laboratory Medicine.

In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement...

Πίνακας περιεχομένων:

• 1. Section 1. RNome: Evolution and nature
• Chapter. 1.1. RNA world hypothesis
• Chapter.1.2. Various classes of RNAs (coding as well non-coding), their biosynthesis and basic functions
• 2. Section 2. Cellular RNome: Chromatin dynamics
• Chapter. 2.1. Chromatin modifications & transcription
• Chapter. 2.2. RNA modifications and epitranscriptomics
• Chapter. 2.3. Cellular RNome: Contribution of non-coding RNA
• 3. Section 3. Cancer RNome: Evolution and Sustenance.(How is cancer RNome different from RNome of healthy cell? How does the cancer RNome regulate the evolution as well as the sustenance of cancer?)
• Chapter. 3.1. Genome instability and mutation
• Chapter. 3.2. Tumor-promoting inflammation
• Chapter. 3.3. DNA methylation addiction
• Chapter. 3.4. Oncoviruses
• Chapter. 3.5. Sustained proliferative signaling
• Chapter. 3.6. Evasion of growth suppressors
• Chapter. 3.7. Replicative immortality
• Chapter. 3.8. Resisting Cell death
• Chapter. 3.9. Invasion and metastasis
• Chapter. 3.10. Angiogenesis induction.-Chapter. 3.11. Deregulated cellular energetics/Molecular sweet tooth
• Chapter. 3.12. Tumor Immune-evasion
• Chapter. 3.13. Cancer stem cells and tumor cell plasticity
• 4. Section 4. Cancer RNome: Therapeutic implications(Translational implications of the cancer RNome). Chapter. 4.1. RNAs as diagnostic/prognostic biomarkers
• Chapter. 4.2. RNAs in cancer therapy & chemo-resistance.