Synthesis of Therapeutic Oligonucleotides

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Obika, Satoshi (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Sekine, Mitsuo (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Θέματα: Pharmaceutical technology.; Medicinal chemistry.; Molecular biology.; Pharmaceutical Sciences/Technology.; Medicinal Chemistry.; Molecular Medicine.

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleot...

Πίνακας περιεχομένων:

• Part 1. Synthesis of Natural Oligonucleotides
• Chapter 1. Non-protected Synthesis of Oligonucleotides
• Chapter 2. Various Coupling Agents in the Phosphoramidite Method for Efficient Oligonucleotide Synthesis
• Chapter 3. Recent Development of Chemical Synthesis of RNA
• Chapter 4. RNA Synthesis Using the CEM Group
• Chapter 5. Liquid-Phase Synthesis of Oligonucleotides
• Chapter 6. Large-Scale Oligonucleotide Manufacturing
• Part 2: Synthesis and Properties of Artificial Oligonucleotides
• Chapter 1. Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modified Nucleobases
• Chapter 2. Site-Specific Modification of nucleobases in oligonucleotides
• Chapter 3. Four-Hydrogen-Bonding Base Pairs in Oligonucleotides: Design, Synthesis, and Properties
• Chapter 4. Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Property of 3-Cyanovinylcarbazole-modified Nucleic Acids and Its Photo-induced Gene-Silencing Activity in Cells
• Chapter 5. Effects of 2´-O-Modifications on RNA Duplex Stability
• Chapter 6. 2',4'-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety
• Chapter 7. Synthesis and Therapeutic Applications of Oligonucleotides Containing 2'-O,4'-C-Ethylene- and 3'-O,4'-C-Propylene-Bridged Nucleotides
• Chapter 8. RNA Bioisosters: Chemistry and Properties of 4'-ThioRNA and 4'-SelenoRNA
• Chapter 9. Development of Triplex Forming Oligonucleotide including Artificial Nucleoside Analogues for the Antigene Strategy
• Chapter 10. Chemical Synthesis of Boranophosphate Deoxyribonucleotides.