Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions

• Κύριος συγγραφέας: Yan Shan, Ang (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Έκδοση: 1st ed. 2018.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Biochemical engineering.; Bioinformatics.; Nanotechnology.; Systems biology.; Biological systems.; Biochemical Engineering.; Computational Biology/Bioinformatics.; Nanotechnology and Microengineering.; Systems Biology.

This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that c...

Πίνακας περιεχομένων:

• Introduction
• Literature Review
• Materials and Methods
• Modular Framework for Engineering a Self-Contained DNA Circuit
• Designing Hybridization Chain Reaction Monomers for Robust Signal Amplification
• Design Concepts in Association Toehold for Robust Signal Transduction
• DNA Split Proximity Circuit as a General Platform for Interrogating Biomolecular Events
• DNA Split Proximity Circuit for Visualizing Cell Surface Receptor Clustering- A Case Study Using Human Epidermal Growth Factor Receptor Family
• Conclusion and Future Outlooks.