Diabetes Mellitus A risk factor for Alzheimer's Disease /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Nakabeppu, Yusaku (Editor, http://id.loc.gov/vocabulary/relators/edt), Ninomiya, Toshiharu (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1128
• Subjects: Neurosciences.; Diabetes.; Neurology .; Neurology.

This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer's disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintena...

Table of Contents:

• Chapter 1 Origins of brain insulin and its function
• Chapter 2 Epidemiological evidence of the relationship between diabetes and dementia
• Chapter 3 Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer's Disease Brain
• Chapter 4 The Full Spectrum of Alzheimer's Disease is Rooted in Metabolic
• Derangements That Drive Type 3 Diabetes
• Chapter 5 The roles of apolipoprotein E, lipids and glucose in the pathogenesis of Alzheimer's disease
• Chapter 6 Molecular connection between diabetes and dementia
• Chapter 7 Type II Diabetes mellitus accelerates age-dependent A pathology in cynomolgus monkey brain
• Chapter 8 Diabetes-related dementia
• Chapter 9 Tortuous paths of insulin signaling and mitochondria in Alzheimer's disease
• Chapter 10 Mammalian target of rapamycin at the crossroad between Alzheimer's Disease and diabetes
• Chapter 11 Therapeutic strategies for Alzheimer's disease in the view of diabetes mellitus.