Progranulin and Central Nervous System Disorders

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hara, Hideaki (Editor, http://id.loc.gov/vocabulary/relators/edt), Hosokawa, Masato (Editor, http://id.loc.gov/vocabulary/relators/edt), Nakamura, Shinsuke (Editor, http://id.loc.gov/vocabulary/relators/edt), Shimohata, Takayoshi (Editor, http://id.loc.gov/vocabulary/relators/edt), Nishihara, Masugi (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Subjects: Medical genetics.; Molecular biology.; Proteins .; Neurosciences.; Gene Function.; Molecular Medicine.; Protein Science.

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases...

Table of Contents:

• Chapter 1. Molecular and Functional Properties of Progranulin
• Chapter 2. Progranulin as a biomarker for neurodegenerative diseases
• Chapter 3. PGRN and FTLD
• Chapter 4. PGRN and neurodegenerative diseases other than FTLD
• Chapter 5. Progranulin Regulations of Lysosomal Homeostasis and its Involvement in Neurodegenerative Diseases
• Chapter 6. Molecular and Functional Properties of Progranulin
• Chapter 7. PGRN and neuroinflammation
• Chapter 8. Neural Stem/Progenitor Cells and Progranulin
• Chapter 9. Generation and phenotyping of progranulin-deficient mice
• Chapter 10. Pleiotropic protective effects of progranulin in the treatment of ischemic stroke
• Chapter 11. New therapeutic approaches against ocular diseases.