Leukemia Stem Cells in Hematologic Malignancies

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Zhang, Haojian (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Li, Shaoguang (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Advances in Experimental Medicine and Biology, 1143
• Θέματα: Cancer research.; Stem cells.; Cancer Research.; Stem Cells.
• Φυσική περιγραφή: VIII, 229 p. 40 illus., 37 illus. in color. online resource.
• ISBN: 9789811373428
• ISSN: 0065-2598 ;
• DOI: 10.1007/978-981-13-7342-8

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.