Leukemia Stem Cells in Hematologic Malignancies

• Corporate Author: SpringerLink (Online service)
• Other Authors: Zhang, Haojian (Editor, http://id.loc.gov/vocabulary/relators/edt), Li, Shaoguang (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1143
• Subjects: Cancer research.; Stem cells.; Cancer Research.; Stem Cells.

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the...

Table of Contents:

• Role of leukemia stem cells in pathogenesis of hematologic malignancies
• Leukemia stem cells in chronic myeloid leukemia
• Leukmeia stem cells in MLL-rearranged acute myeloid leukemia
• Interaction between leukmeia stem cells and bone marrow environment
• Molecular signatures of leukemia stem cells
• Metabolic regulation of leukemia stem cell function
• Epigenetic regulation of leukmeia stem cell function
• DNA instability and leukemia stem cell function
• Tumor suppressor genes in leukemia stem cells
• Targeting leukemia stem cells
• Leukemia stem cells and drug resistance
• Hypoxia and leukemia.