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03697nam a2200517 4500 |
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978-981-13-7450-0 |
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DE-He213 |
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20191113185848.0 |
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|a 9789811374500
|9 978-981-13-7450-0
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|a 10.1007/978-981-13-7450-0
|2 doi
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|a 616.96
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|a Actin Polymerization in Apicomplexan
|h [electronic resource] :
|b A Structural, Functional and Evolutionary Analysis /
|c edited by Avinash Kale.
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|a 1st ed. 2019.
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|a Singapore :
|b Springer Singapore :
|b Imprint: Springer,
|c 2019.
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| 300 |
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|a XI, 101 p. 11 illus. in color.
|b online resource.
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|a text
|b txt
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|b PDF
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|a Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.
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|a This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
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|a Parasitology.
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|a Biomechanics.
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|a Proteins .
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| 650 |
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|a Bioinformatics.
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|a Parasitology.
|0 http://scigraph.springernature.com/things/product-market-codes/B19002
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| 650 |
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|a Biomechanics.
|0 http://scigraph.springernature.com/things/product-market-codes/L29020
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| 650 |
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|a Protein Science.
|0 http://scigraph.springernature.com/things/product-market-codes/L14040
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| 650 |
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|a Protein Structure.
|0 http://scigraph.springernature.com/things/product-market-codes/L14050
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| 650 |
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|a Bioinformatics.
|0 http://scigraph.springernature.com/things/product-market-codes/L15001
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| 700 |
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|a Kale, Avinash.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9789811374494
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| 776 |
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|i Printed edition:
|z 9789811374517
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| 776 |
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|i Printed edition:
|z 9789811374524
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| 856 |
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|u https://doi.org/10.1007/978-981-13-7450-0
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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