Drug Transporters in Drug Disposition, Effects and Toxicity

• Corporate Author: SpringerLink (Online service)
• Other Authors: Liu, Xiaodong (Editor, http://id.loc.gov/vocabulary/relators/edt), Pan, Guoyu (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1141
• Subjects: Pharmacology.; Pharmacy.; Medicinal chemistry.; Pharmacology/Toxicology.; Drug Safety and Pharmacovigilance.; Medicinal Chemistry.

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided...

Table of Contents:

• Overview: role of drug transporters in drug disposition and its clinical significance
• ABC family transporters
• SLC family transporters
• Current research method in transporter study
• Transporter-mediated drug-drug interactions and their significance
• Roles of hepatic drug transporters in drug disposition and liver toxicity
• Roles of renal drug transporter in drug disposition and renal toxicity
• Intestinal transporter associated toxicity and absorption
• Contributions of drug transporters to blood-brain barriers
• Contributions of drug transporters to blood-retinal barrier(BRB)
• Contributions of drug transporters to blood-placental barrier
• ABC transporter-mediated multidrug-resistant cancer.