Therapeutic Enzymes: Function and Clinical Implications

This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of severa...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή:	SpringerLink (Online service)
Άλλοι συγγραφείς:	Labrou, Nikolaos (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
Μορφή:	Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:	English
Έκδοση:	Singapore : Springer Singapore : Imprint: Springer, 2019.
Έκδοση:	1st ed. 2019.
Σειρά:	Advances in Experimental Medicine and Biology, 1148
Θέματα:	Proteins . Protein Science.
Διαθέσιμο Online:	Full Text via HEAL-Link

Πίνακας περιεχομένων:

Chapter 1. Introduction to therapeutic enzymes
Chapter 2. Upstream processing technologies
Chapter 3. Downstream processing technologies
Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations
Chapter 5. Regulatory guidance in the production of therapeutic enzymes
Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics Bertrand Raynal Patrick England
Chapter 7. Clinical Development of a therapeutic enzyme
Chapter 8. Chemical modifications of therapeutic proteins
Chapter 9. Formulation of therapeutic enzymes
Chapter 10. Engineering of therapeutic enzymes for improving activity
Chapter 11. Engineering of therapeutic enzymes for improving stability
Chapter 12. Design and engineering of deimmunized therapeutic enzymes
Chapter 13. Nanoparticles for delivery of therapeutic enzymes
Chapter 14. Targeted delivery of therapeutic enzymes
Chapter 15. Oral and inhalable enzyme therapies
Chapter 16. Regulatory issues
Chapter 17. Enzyme replacement therapies
Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy
Chapter 19. Enzyme therapy for lysosomal storage disorders
Chapter 20. Enzyme therapy for myocardial infarction
Chapter 21. Enzyme therapy for chronic gout
Chapter 22. Enzyme therapy for tumor lysis syndrome
Chapter 23. Enzyme therapy for collagen-based disorders
Chapter 24. Enzyme therapy for severe combined immunodeficiency disease
Chapter 25. Enzyme therapy for detoxification of methotrexate
Chapter 26. Enzyme therapy vitreomacular adhesion
Chapter 27. L-Asparaginase as anticancer agent
Chapter 28. Pancreatic enzyme replacement therapy
Chapter 29. Enzymes in metabolic anticancer therapy
Chapter 30. L-Arginase for L-Arg depletion therapy in cancer
Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer
Chapter 32. Enzyme therapy for celiac sprue
Chapter 33. Acid ceramidase
Chapter 34. Lysosomal acid lipase
Chapter 35. Alkaline phosphatase and hypophosphatasia
Chapter 36. Enzybiotics: Antibiotic enzymes as drugs and therapeutics
Chapter 37. Anti-inflammatory enzymes
Chapter 38. Phenylalanine ammonia lyase for the treatment of phenylketonuria
Chapter 39. Clinical applications of Hyaluronidase
Chapter 40. Superoxide dismutase and oxidative stress modulation
Chapter 41. Organophosphate hydrolases as catalytic bioscavengers
Chapter 42. Novel therapeutic proteases
Chapter 43. Genome-editing enzymes
Chapter 44. Gene therapy for enzyme deficiency: current status and future prospects.

Therapeutic Enzymes: Function and Clinical Implications

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