Histone Deacetylase Inhibitors - Epidrugs for Neurological Disorders

• Κύριος συγγραφέας: Ganai, Shabir Ahmad (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Θέματα: Neurosciences.; Pharmacology.; Genetics.; Proteins .; Posttranslational modification.; Pharmacology/Toxicology.; Genetics and Genomics.; Protein Science.; Posttranslational Modification.

This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological...

Πίνακας περιεχομένων:

• Chapter 1. Role of Epigenetics in neurological diseases
• Chapter 2. Epigenetic enzymes and the drawbacks of conventional therapeutic regimens
• Chapter 3. Distinct classes of HDACs
• Chapter 4. HDAC implications in neurological diseases
• Chapter 5. HDAC inhibitors and their structurally distinct groups
• Chapter 6. HDAC inhibitors as novel therapeutic option against therapeutically challenging neurological disorders
• Chapter 7. Current Challenges with HDAC inhibitor based therapeutic intervention against neurological maladies
• Chapter 8. Escalating need of isoform selective inhibitors for enhanced therapeutic efficacy
• Chapter 9. Combinatorial therapeutic regimens using HDAC inhibitors in conjunction with conventional therapeutic agents
• Chapter 10. Future directions of epigenetic research in tackling neurological complications.