In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Takebayashi, Toru (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Landsiedel, Robert (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Gamo, Masashi (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Current Topics in Environmental Health and Preventive Medicine,
• Θέματα: Health promotion.; Health administration.; Pharmacology.; Health Promotion and Disease Prevention.; Health Administration.; Pharmacology/Toxicology.

This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomateri...

Πίνακας περιεχομένων:

• 1 The role of in vivo screening studies in assessing manufactured nanomaterials
• Part 1 Short Term Inhalation Study
• 2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy
• 3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies
• 4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) - Does nanofiber exposure have adverse impacts on the cardiovascular system?
• Part 2 Intratracheal Administration Study
• 5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles
• 6. Standardization of intratracheal instillation study of manufactured nanomaterials
• 7. Sample preparation and the chracterization for Intratracheal Administration
• 8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes
• 9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration
• 10. Toxicokinetics of nano materials after the intratracheal administration
• 11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles. .