Protein Allostery in Drug Discovery
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric dru...
| Συγγραφή απο Οργανισμό/Αρχή: | |
|---|---|
| Άλλοι συγγραφείς: | , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Singapore :
Springer Singapore : Imprint: Springer,
2019.
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| Έκδοση: | 1st ed. 2019. |
| Σειρά: | Advances in Experimental Medicine and Biology,
1163 |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Chapter 1. Allostery in Drug Development
- Chapter 2. Dynamic Protein Allosteric Regulation and Disease
- Chapter 3. Protein Allostery in Rational Drug Design
- Chapter 4. Progress in Allosteric Database
- Chapter 5. Correlation between Allosteric and Orthosteric Sites
- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators
- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins
- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands
- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network
- Chapter 10. GPCR Allosteric Modulator Discovery
- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors
- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs)
- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins
- Chapter 15. Engineering Allostery into Proteins.
