Protein Allostery in Drug Discovery

• Corporate Author: SpringerLink (Online service)
• Other Authors: Zhang, Jian (Editor, http://id.loc.gov/vocabulary/relators/edt), Nussinov, Ruth (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Advances in Experimental Medicine and Biology, 1163
• Subjects: Pharmaceutical technology.; Proteins .; Biomedical engineering.; Pharmaceutical Sciences/Technology.; Protein Science.; Protein Structure.; Biomedical Engineering/Biotechnology.

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric dru...

Table of Contents:

• Chapter 1. Allostery in Drug Development
• Chapter 2. Dynamic Protein Allosteric Regulation and Disease
• Chapter 3. Protein Allostery in Rational Drug Design
• Chapter 4. Progress in Allosteric Database
• Chapter 5. Correlation between Allosteric and Orthosteric Sites
• Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators
• Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins
• Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands
• Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network
• Chapter 10. GPCR Allosteric Modulator Discovery
• Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors
• Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs)
• Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins
• Chapter 15. Engineering Allostery into Proteins.