Clinical Epigenetics

• Corporate Author: SpringerLink (Online service)
• Other Authors: Hesson, Luke B. (Editor, http://id.loc.gov/vocabulary/relators/edt), Pritchard, Antonia L. (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Subjects: Gene expression.; Medical genetics.; Gene therapy.; Cytogenetics.; Molecular biology.; Gene Expression.; Gene Function.; Gene Therapy.; Molecular Medicine.

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (sci...

Table of Contents:

• Genetics and epigenetics: a Historical Overview
• The DNA methylation machinery
• Methylcytosine and its oxidised derivatives
• The role of nucleosomes in epigenetic gene regulation
• Circular RNAs in human health and disease
• The role of histone variants in cancer
• DNA methylation and carcinogenesis: Current and future perspectives
• Dysregulation of cis-regulatory elements in cancer
• Germline epigenetic testing of imprinting disorders in a diagnostic setting
• Cancer methylation biomarkers in circulating cell-free DNA
• The clinical utility of epigenetics.