SIRT6 Activities in DNA Damage Repair and Premature Aging Functions of SIRT6 /

• Κύριος συγγραφέας: Ghosh, Shrestha (Συγγραφέας, http://id.loc.gov/vocabulary/relators/aut)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Έκδοση: 1st ed. 2019.
• Σειρά: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Θέματα: Human genetics.; Cell biology.; Human Genetics.; Cell Biology.

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT...

Πίνακας περιεχομένων:

• Introduction
• Materials and Methods
• Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process
• Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice
• Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase
• Discussion.