SIRT6 Activities in DNA Damage Repair and Premature Aging Functions of SIRT6 /

• Main Author: Ghosh, Shrestha (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2019.
• Edition: 1st ed. 2019.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Human genetics.; Cell biology.; Human Genetics.; Cell Biology.

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT...

Table of Contents:

• Introduction
• Materials and Methods
• Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process
• Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice
• Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase
• Discussion.