Tau Biology
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various...
| Corporate Author: | |
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| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Singapore :
Springer Singapore : Imprint: Springer,
2019.
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| Edition: | 1st ed. 2019. |
| Series: | Advances in Experimental Medicine and Biology,
1184 |
| Subjects: | |
| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- 1) Structure and role of Tau molecule
- (1) Tau structure in solution: FRET study
- (2) Tau structure in solution: NMR study
- (3) Structure of NFT: Biochemical approach
- (4) Structure of NFT: CryoEM approach
- (5) MAPT tau gene and FTDP-17 mutation
- (6) Tau phosphorylation
- (7) Tau acetylation
- (8) Tau truncation
- (9) Tau interacted proteins: interactome
- (10) Tau clearance mechanism
- 2) Tau localization and function
- (11) Localization of Tau
- (12) Axonal transport
- (13) Synaptic localization of tau
- (14) Role of tau in synapse
- (15) Tau in nucleus and nucleic acids
- (16) Tau and the translational stress response
- 3) Tauopathies; pathology, drivers, and marker
- (17) Tau pathology with aging
- (18) Clinical symptom and pathology of FTD including FTDP-17
- (19) Chronic Traumatic Encephalopathy
- (20) Myotonic dystrophies
- (21) Tau PET
- (22) Tau PET/connectome/fMRI
- (23) Stress
- (24) Diabetes
- (25) Relationship between ApoE and tau
- (26) Relationship between Ab and tau
- 4) Tau aggregation, and therapy
- (27) Tau Oligomer
- (28) Tau droplet formation
- (29) Stress granule
- (30) Tau secretion
- (31) Tau seeding
- (32) Prion-like Tau propagation
- (33) Experimental models for tauopathies
- (34) Dementia therapy targeting tau
- (35) Tau aggregation inhibitor.
