Co-signal Molecules in T Cell Activation Immune Regulation in Health and Disease /

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Azuma, Miyuki (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt), Yagita, Hideo (Επιμελητής έκδοσης, http://id.loc.gov/vocabulary/relators/edt)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Singapore : Springer Singapore : Imprint: Springer, 2019.
Έκδοση:1st ed. 2019.
Σειρά:Advances in Experimental Medicine and Biology, 1189
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 04271nam a2200541 4500
001 978-981-32-9717-3
003 DE-He213
005 20191205161306.0
007 cr nn 008mamaa
008 191122s2019 si | s |||| 0|eng d
020 |a 9789813297173  |9 978-981-32-9717-3 
024 7 |a 10.1007/978-981-32-9717-3  |2 doi 
040 |d GrThAP 
050 4 |a QR180-189.5 
072 7 |a MJCM  |2 bicssc 
072 7 |a MED044000  |2 bisacsh 
072 7 |a MJCM  |2 thema 
082 0 4 |a 616.079  |2 23 
245 1 0 |a Co-signal Molecules in T Cell Activation  |h [electronic resource] :  |b Immune Regulation in Health and Disease /  |c edited by Miyuki Azuma, Hideo Yagita. 
250 |a 1st ed. 2019. 
264 1 |a Singapore :  |b Springer Singapore :  |b Imprint: Springer,  |c 2019. 
300 |a VI, 326 p. 22 illus., 21 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Advances in Experimental Medicine and Biology,  |x 0065-2598 ;  |v 1189 
505 0 |a Part I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. . 
520 |a This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. . 
650 0 |a Immunology. 
650 0 |a Cancer research. 
650 0 |a Neurology . 
650 0 |a Oncology  . 
650 1 4 |a Immunology.  |0 http://scigraph.springernature.com/things/product-market-codes/B14000 
650 2 4 |a Cancer Research.  |0 http://scigraph.springernature.com/things/product-market-codes/B11001 
650 2 4 |a Neurology.  |0 http://scigraph.springernature.com/things/product-market-codes/H36001 
650 2 4 |a Oncology.  |0 http://scigraph.springernature.com/things/product-market-codes/H33160 
700 1 |a Azuma, Miyuki.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Yagita, Hideo.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9789813297166 
776 0 8 |i Printed edition:  |z 9789813297180 
776 0 8 |i Printed edition:  |z 9789813297197 
830 0 |a Advances in Experimental Medicine and Biology,  |x 0065-2598 ;  |v 1189 
856 4 0 |u https://doi.org/10.1007/978-981-32-9717-3  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)