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|a 9789813297173
|9 978-981-32-9717-3
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|a 10.1007/978-981-32-9717-3
|2 doi
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|a Co-signal Molecules in T Cell Activation
|h [electronic resource] :
|b Immune Regulation in Health and Disease /
|c edited by Miyuki Azuma, Hideo Yagita.
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|a 1st ed. 2019.
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|a Singapore :
|b Springer Singapore :
|b Imprint: Springer,
|c 2019.
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|a VI, 326 p. 22 illus., 21 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
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|a text file
|b PDF
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1189
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|a Part I: Basic Understanding of Co-signal Molecules in T cell activation -- Chapter 1 Co-signal molecules in T cell activation -- Chapter 2 The CD28-B7 family of co-signaling molecules -- Chapter 3 The TNF YNFR family of co-signal molecules -- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors -- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation -- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation -- Chapter 7 Control of regulatory T cells by co-signal molecules -- Part II: Co-signal Molecules in Health and Disease -- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity -- Chapter 9 Co-signaling molecules in neurological diseases -- Chapter 10 Costimulation blockade in transplantation -- Chapter 11 Immunotherapy targeting co-signal molecules. .
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|a This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. .
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|a Immunology.
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|a Cancer research.
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|a Neurology .
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|a Oncology .
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|a Immunology.
|0 http://scigraph.springernature.com/things/product-market-codes/B14000
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|a Cancer Research.
|0 http://scigraph.springernature.com/things/product-market-codes/B11001
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|a Neurology.
|0 http://scigraph.springernature.com/things/product-market-codes/H36001
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|a Oncology.
|0 http://scigraph.springernature.com/things/product-market-codes/H33160
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|a Azuma, Miyuki.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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|a Yagita, Hideo.
|e editor.
|4 edt
|4 http://id.loc.gov/vocabulary/relators/edt
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710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9789813297166
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776 |
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|i Printed edition:
|z 9789813297180
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|i Printed edition:
|z 9789813297197
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830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 1189
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856 |
4 |
0 |
|u https://doi.org/10.1007/978-981-32-9717-3
|z Full Text via HEAL-Link
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|a ZDB-2-SBL
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950 |
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|a Biomedical and Life Sciences (Springer-11642)
|