Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors

Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of t...

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Κύριος συγγραφέας: Papatheodoropoulos, Costas
Άλλοι συγγραφείς: Παπαθεοδωρόπουλος, Κώστας
Μορφή: Journal (paper)
Γλώσσα:English
Έκδοση: 2017
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Διαθέσιμο Online:http://hdl.handle.net/10889/10746
id nemertes-10889-10746
record_format dspace
spelling nemertes-10889-107462022-09-05T05:38:39Z Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors Papatheodoropoulos, Costas Παπαθεοδωρόπουλος, Κώστας Hippocampus Septotemporal Dorsoventral Excitability Inhibition Disinhibition Networks GABAA receptors GABAB receptors NMDA receptors Ιππόκαμπος Αναχαίτηση Αποκλεισμός Δίκτυα Υποδοχείς GABAA Υποδοχείς GABAB Υποδοχείς NMDA Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of this study was to characterize spontaneous network activity between the dorsal and the ventral hippocampus induced under conditions of partial or complete blockade of GABAergic inhibition (i.e. disinhibition). Results: Using field recordings from the CA3 and CA1 fields of hippocampal slices from adult rats I found that ventral compared with dorsal hippocampus slices displayed higher propensity for and higher frequency of occurrence of spontaneous field potentials (spfps) at every level of disinhibition. Also NMDA receptor-depended spfps (spfps-nmda) occurred with higher probability more frequently and were larger in the ventral compared with the dorsal hippocampus. Importantly, blockade of GABAB receptors produced a stronger effect in enhancing the probability of generation of spfps and spfps-nmda in the dorsal compared with the ventral hippocampal slices and increased spfps-nmda only in dorsal slices. Conclusion: These results demonstrate a higher intrinsic neuronal excitability of the ventral compared with the dorsal local circuitry with the considerable contribution of NMDA receptors. Furthermore, the GABAB receptors control the total and the NMDA receptor-dependent excitation much less effectively in the ventral part of the hippocampus. It is proposed that NMDA and GABAB receptors significantly contribute to differentiate local network dynamics between the dorsal and the ventral hippocampus with important implications in the information processing performed along the long hippocampal axis. -- 2017-10-25T11:48:44Z 2017-10-25T11:48:44Z 2015 Journal (paper) Papatheodoropoulos, C. (2015). Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors. BMC Neuroscience, 16(1), 1–11. doi:10.1186/s12868-015-0213-z http://hdl.handle.net/10889/10746 en application/pdf BMC Neurosci
institution UPatras
collection Nemertes
language English
topic Hippocampus
Septotemporal
Dorsoventral
Excitability
Inhibition
Disinhibition
Networks
GABAA receptors
GABAB receptors
NMDA receptors
Ιππόκαμπος
Αναχαίτηση
Αποκλεισμός
Δίκτυα
Υποδοχείς GABAA
Υποδοχείς GABAB
Υποδοχείς NMDA
spellingShingle Hippocampus
Septotemporal
Dorsoventral
Excitability
Inhibition
Disinhibition
Networks
GABAA receptors
GABAB receptors
NMDA receptors
Ιππόκαμπος
Αναχαίτηση
Αποκλεισμός
Δίκτυα
Υποδοχείς GABAA
Υποδοχείς GABAB
Υποδοχείς NMDA
Papatheodoropoulos, Costas
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
description Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of this study was to characterize spontaneous network activity between the dorsal and the ventral hippocampus induced under conditions of partial or complete blockade of GABAergic inhibition (i.e. disinhibition). Results: Using field recordings from the CA3 and CA1 fields of hippocampal slices from adult rats I found that ventral compared with dorsal hippocampus slices displayed higher propensity for and higher frequency of occurrence of spontaneous field potentials (spfps) at every level of disinhibition. Also NMDA receptor-depended spfps (spfps-nmda) occurred with higher probability more frequently and were larger in the ventral compared with the dorsal hippocampus. Importantly, blockade of GABAB receptors produced a stronger effect in enhancing the probability of generation of spfps and spfps-nmda in the dorsal compared with the ventral hippocampal slices and increased spfps-nmda only in dorsal slices. Conclusion: These results demonstrate a higher intrinsic neuronal excitability of the ventral compared with the dorsal local circuitry with the considerable contribution of NMDA receptors. Furthermore, the GABAB receptors control the total and the NMDA receptor-dependent excitation much less effectively in the ventral part of the hippocampus. It is proposed that NMDA and GABAB receptors significantly contribute to differentiate local network dynamics between the dorsal and the ventral hippocampus with important implications in the information processing performed along the long hippocampal axis.
author2 Παπαθεοδωρόπουλος, Κώστας
author_facet Παπαθεοδωρόπουλος, Κώστας
Papatheodoropoulos, Costas
format Journal (paper)
author Papatheodoropoulos, Costas
author_sort Papatheodoropoulos, Costas
title Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
title_short Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
title_full Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
title_fullStr Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
title_full_unstemmed Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
title_sort higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by gabab receptors
publishDate 2017
url http://hdl.handle.net/10889/10746
work_keys_str_mv AT papatheodoropouloscostas higherintrinsicnetworkexcitabilityinventralcomparedwiththedorsalhippocampusiscontrolledlesseffectivelybygababreceptors
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