Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors
Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of t...
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nemertes-10889-107462022-09-05T05:38:39Z Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors Papatheodoropoulos, Costas Παπαθεοδωρόπουλος, Κώστας Hippocampus Septotemporal Dorsoventral Excitability Inhibition Disinhibition Networks GABAA receptors GABAB receptors NMDA receptors Ιππόκαμπος Αναχαίτηση Αποκλεισμός Δίκτυα Υποδοχείς GABAA Υποδοχείς GABAB Υποδοχείς NMDA Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of this study was to characterize spontaneous network activity between the dorsal and the ventral hippocampus induced under conditions of partial or complete blockade of GABAergic inhibition (i.e. disinhibition). Results: Using field recordings from the CA3 and CA1 fields of hippocampal slices from adult rats I found that ventral compared with dorsal hippocampus slices displayed higher propensity for and higher frequency of occurrence of spontaneous field potentials (spfps) at every level of disinhibition. Also NMDA receptor-depended spfps (spfps-nmda) occurred with higher probability more frequently and were larger in the ventral compared with the dorsal hippocampus. Importantly, blockade of GABAB receptors produced a stronger effect in enhancing the probability of generation of spfps and spfps-nmda in the dorsal compared with the ventral hippocampal slices and increased spfps-nmda only in dorsal slices. Conclusion: These results demonstrate a higher intrinsic neuronal excitability of the ventral compared with the dorsal local circuitry with the considerable contribution of NMDA receptors. Furthermore, the GABAB receptors control the total and the NMDA receptor-dependent excitation much less effectively in the ventral part of the hippocampus. It is proposed that NMDA and GABAB receptors significantly contribute to differentiate local network dynamics between the dorsal and the ventral hippocampus with important implications in the information processing performed along the long hippocampal axis. -- 2017-10-25T11:48:44Z 2017-10-25T11:48:44Z 2015 Journal (paper) Papatheodoropoulos, C. (2015). Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors. BMC Neuroscience, 16(1), 1–11. doi:10.1186/s12868-015-0213-z http://hdl.handle.net/10889/10746 en application/pdf BMC Neurosci |
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Nemertes |
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English |
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Hippocampus Septotemporal Dorsoventral Excitability Inhibition Disinhibition Networks GABAA receptors GABAB receptors NMDA receptors Ιππόκαμπος Αναχαίτηση Αποκλεισμός Δίκτυα Υποδοχείς GABAA Υποδοχείς GABAB Υποδοχείς NMDA |
spellingShingle |
Hippocampus Septotemporal Dorsoventral Excitability Inhibition Disinhibition Networks GABAA receptors GABAB receptors NMDA receptors Ιππόκαμπος Αναχαίτηση Αποκλεισμός Δίκτυα Υποδοχείς GABAA Υποδοχείς GABAB Υποδοχείς NMDA Papatheodoropoulos, Costas Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
description |
Background: Elucidating specializations of the intrinsic neuronal network between the dorsal and the ventral hippocampus is a recently emerging area of research that is expected to help us understand the mechanisms underlying large scale functional diversification along the hippocampus. The aim of this study was to characterize spontaneous network activity between the dorsal and the ventral hippocampus induced under conditions of partial or complete blockade of GABAergic inhibition (i.e. disinhibition). Results: Using field recordings from the CA3 and CA1 fields of hippocampal slices from adult rats I found that ventral compared with dorsal hippocampus slices displayed higher propensity for and higher frequency of occurrence of spontaneous field potentials (spfps) at every level of disinhibition. Also NMDA receptor-depended spfps (spfps-nmda) occurred with higher probability more frequently and were larger in the ventral compared with the dorsal hippocampus. Importantly, blockade of GABAB receptors produced a stronger effect in enhancing the probability of generation of spfps and spfps-nmda in the dorsal compared with the ventral hippocampal slices and increased spfps-nmda only in dorsal slices. Conclusion: These results demonstrate a higher intrinsic neuronal excitability of the ventral compared with the dorsal local circuitry with the considerable contribution of NMDA receptors. Furthermore, the GABAB receptors control the total and the NMDA receptor-dependent excitation much less effectively in the ventral part of the hippocampus. It is proposed that NMDA and GABAB receptors significantly contribute to differentiate local network dynamics between the dorsal and the ventral hippocampus with important implications in the information processing performed along the long hippocampal axis. |
author2 |
Παπαθεοδωρόπουλος, Κώστας |
author_facet |
Παπαθεοδωρόπουλος, Κώστας Papatheodoropoulos, Costas |
format |
Journal (paper) |
author |
Papatheodoropoulos, Costas |
author_sort |
Papatheodoropoulos, Costas |
title |
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
title_short |
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
title_full |
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
title_fullStr |
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
title_full_unstemmed |
Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors |
title_sort |
higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by gabab receptors |
publishDate |
2017 |
url |
http://hdl.handle.net/10889/10746 |
work_keys_str_mv |
AT papatheodoropouloscostas higherintrinsicnetworkexcitabilityinventralcomparedwiththedorsalhippocampusiscontrolledlesseffectivelybygababreceptors |
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1771297154600534016 |