Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor

• Main Authors: Koutsioumpa, Marina, Poimenidi, Evangelia, Pantazaka, Evangelia, Theodoropoulou, Christina, Skoura, Angeliki, Megalooikonomou, Vasileios, Kieffer, Nelly, Courty, Jose, Mizumoto, Shuji, Sugahara, Kazuyuki, Papadimitriou, Evangelia
• Other Authors: Κουτσιούμπα, Μαρίνα
• Format: Journal (paper)
• Language: English
• Published: 2017
• Subjects: Chondroitin sulphate; Endothelial cells; Migration; Pleiotrophin; Tyrosine phosphatases; Vascular endothelial growth factor; Θειική χονδροϊτίνη; Ενδοθηλιακά κύτταρα; Μετανάστευση; Πλειοτροφίνη; Φωσφατάσες τυροσίνης; Αγγειακός ενδοθηλιακός αυξητικός παράγοντας

Background: Receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). RPTPβ/ζ interacts with ανβ3 on the cell surface and upon binding of PTN leads to c-Src dephosphorylation at Tyr5...