The role of the kinases of the nuclear factor -κB in malignant pleural mesothelioma

• Κύριος συγγραφέας: Σίμογλου, Δημήτριος
• Άλλοι συγγραφείς: Σταθόπουλος, Γεώργιος
• Μορφή: Thesis
• Γλώσσα: English
• Έκδοση: 2018
• Θέματα: Kinases; Mesothelioma; NF -κΒ; Κινάσες; Κακόηθες υπεζωκοτικό μεσοθηλίωμα; 616.994 240 6

Malignant pleural mesothelioma is a rare aggressive cancer that develops in the thin layer of tissue surrounding the lungs, known as pleural. The NF-κB transcription factor family is expressed in many types of tissues and plays a key role in triggering specific immune and inflammatory responses to environmental changes. NF-κB activates cellular behavior in many ways: inhibits apoptosis, induces increased cell proliferation, increases inflammation and immune response, etc. The function of the active NF-κB subunits that control all of the above depends on the activity of IKKα and IKΚβ kinases in both NF-κB activation pathways. The purpose of this study is to determine the role of IKKα and IKKβ kinases in malignant pleural mesothelioma. For this purpose, gene expression of IKKα and IKKβ was silenced in AB2 and AE17 mesothelioma cancer cell lines and the potential changes in the proliferation rate of these cells were assessed in vitro. Our results demonstrate that kinase silencing, particularly IKKα, reduces statistically significantly the proliferation rate, which strongly indicates that IKKα kinase actively induces the aggression of cancer cells.