Mutant KRAS promotes malignant pleural effusion formation

• Main Authors: Agalioti, Theodora, Giannou, Anastasios, Krontira, Anthi, Kanellakis, Nikolaos, Kati, Danai, Vreka, Malamati, Pepe, Mario, Spella, Magda, Lilis, Ioannis, Zazara, Dimitra, Nikolouli, Eirini, Spiropoulou, Nikolitsa, Papadakis, Andreas, Papadia, Konstantina, Voulgaridis, Apostolos, Stamou, Panagiota, Meiners, Silke, Eickelberg, Oliver, Snyder, Linda, Antimisiaris, Sophia, Kardamakis, Dimitrios, Psallidas, Ioannis, Marazioti, Antonia, Stathopoulos, Georgios
• Other Authors: Αγαλιώτη, Θεοδώρα
• Format: Journal (paper)
• Language: English
• Published: 2018
• Subjects: Malignant pleural effusion; Mutant KRAS; CCL2; Κακοήθης υπεζωκοτική συλλογή

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant K...