NRAS destines tumor cells to the lungs

• Main Authors: Γιάννου, Αναστάσιος, Μαραζιώτη, Αντωνία, Κανελλάκης, Νικόλαος, Γιοπάνου, Ιωάννα, Λίλης, Ιωάννης, Ζαζάρα, Δήμητρα, Νταλιάρδα, Γιαννούλα, Κατή, Δανάη, Αρμένης, Βασίλειος, Γιωτοπουλου, Γεωργία, Κροντηρά, Ανθή, Λιανου, Μαρίνα, Αγαλιώτη, Θεοδώρα, Βρέκα, Μαλαματή, Παπαγεωργοπούλου, Μαρία, Φούζας, Σωτήριος, Καρδαμάκης, Δημήτριος, Ψαλλίδας, Ιωάννης, Σταθόπουλος, Γεώργιος, Σπέλλα, Μάγδα
• Other Authors: Giannou, Anastasios
• Format: Research papers
• Language: English
• Published: 2018
• Subjects: Pulmonary metastasis; Inflammation and cancer; Interleukin-8-related chemokines; Lung endothelium; Myeloid cells; Νεοπλασματική μετάσταση; Φλεγμονή και καρκίνος; Πνευμονικό ενδοθήλιο; Μυελοειδή κύτταρα

The lungs are frequently affected by cancer metastasis. Although NRAS mutations have been associated with metastatic potential, their exact role in lung homing is incompletely understood. We cross-examined the genotype of various tumor cells with their ability for automatic pulmonary dissemination,...