Molecular mechanisms involved in the anti-tumor effects of lumican and glycosaminoglycans

• Main Author: Καραμάνου, Κωνσταντίνα
• Other Authors: Βύνιος, Δημήτριος
• Format: Thesis
• Language: English
• Published: 2019
• Subjects: Lumican; Proteoglycans; Cancer; Extracellular matrix; Metastasis; Melanoma; Signalling pathways; Λουμικάνη; Πρωτεογλυκάνες; Καρκίνος; Εξωκυττάριος χώρος; Μετάσταση; Μελάνωμα; Σηματοδοτικά μονοπάτια

Extracellular matrix (ECM) is a dynamic complex of macromolecules that regulate cell behavior, gene expression and specific cellular characteristics. Proteoglycans are key molecules of the ECM. They are involved in pathophysiological processes, such as cancer, and are therefore called multifunctiona...