Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications

• Main Author: Ζήνγκου, Ελένη
• Other Authors: Σωτηροπούλου, Γεωργία
• Format: Thesis
• Language: English
• Published: 2019
• Subjects: Skin inflammation; Epidermal overdesquamation; Human kallikrein-related peptidase 5 (KLK5); Netherton syndrome; Skin cancer; Φλεγμονή του δέρματος; Υπεραποφολίδωση; Ανθρώπινη καλλικρεϊνη 5 (KLK5); Σύνδρομο Netherton; Καρκίνος του δέρματος; 616.047 3

Kallikrein-related peptidase 5 (KLK5 for human; Klk5, for mouse) or kallikrein 5 or stratum corneum tryptic enzyme (SCTE) is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated aut...