DNA replication licensing regulation through the cell cycle of embryonic stem cells and cancer cells

• Main Author: Κανέλλου, Αλεξάνδρα
• Other Authors: Λυγερού, Ζωή
• Format: Thesis
• Language: English
• Published: 2020
• Subjects: DNA replication licensing; MCM2-7 helicase complex; Cdc6; Replication stress; Αδειοδότηση της αντιγραφής του DNA; MCM2-7 σύμπλοκο ελικασών; Παράγοντας Cdc6; Αντιγραφικό στρες; 572.864 5

In order to maintain genomic integrity the cells have mechanisms ensuring that DNA is replicated faithfully and only once in each cell cycle. Genomic instability can result from aberrant replication and leads to tumorigenesis. Therefore, DNA replication is under strict regulation. Licensing DNA for...