Investigation of novel multifunctional polydimethylsiloxane nanoparticles as cancer targeting and siRNA polyplex formulation

• Main Author: Cakilkaya, Pinar
• Other Authors: Κλεπετσάνης, Παύλος
• Format: Thesis
• Language: English
• Published: 2020
• Subjects: Nanoparticles; Silicon dioxide; Cancer; PDMS peptides; Νανοσωματίδια; Διοξείδιο του πυριτίου; Καρκίνος; PDMS πεπτίδια

Combining the functions of the prolonged systemic circulation, enhanced tumor targeting and specific intracellular drug release is vital for small molecule drug delivery as well as the nucleic acid formulations. Here, we report a new approach to prepare silica nanoparticles based on self-catalyzed r...