New in vitro models to evaluate intestinal absorption of nanomedicines

• Main Author: Kaeokhamloed, Norraseth
• Other Authors: Κλεπετσάνης, Παύλος
• Format: Thesis
• Language: English
• Published: 2020
• Subjects: Intestinal absorption model; Lipid nanocapsules; Vascular endothelium cell line HMEC-1; Εντερικό πρότυπο απορρόφησης; Λιπιδικές νανοκάψουλες; Κυτταρική σειρά αγγειακού ενδοθηλίου HMEC-1

The complex properties of nanoparticles that differ from conventional molecular drug necessitate the need for better in vitro cell culture model to study their absorption behavior. Standard models like Caco-2 seems to be inadequate because it consists of only one intestinal epithelium monolayer, ign...