Role of α-synuclein in the pathogenesis and progression of Parkinson’s disease

• Main Author: Συκιώτη, Βάσια-Σαμάνθα
• Other Authors: Sykioti, Vasia-Samantha
• Language: English
• Published: 2020
• Subjects: Parkinson disease; Synucleinopathies; Alpha-synuclein; Microdialysis; Νόσος του Πάρκινσον; α-συνουκλεΐνη

Several lines of evidence indicate that the propagation of misfolded α-synuclein (α-syn) plays a fundamental role in the initiation and progression of Parkinson’s disease (PD). Considering that the cell-to-cell transfer of misfolded α-syn entails its release accompanied by internalization, focusing...