Development and validation of phosphonate-based inhibitors and activity-based probes (ABPs) for detection and pharmacological targeting of kallikreins

• Κύριος συγγραφέας: Μπισύρης, Ευάγγελος
• Άλλοι συγγραφείς: Bisyris, Evangelos
• Γλώσσα: English
• Έκδοση: 2021
• Θέματα: Kallikrein 7; Activity-based probes; Theranostics; Serine protease inhibitors; Atopic dermatitis; Netherton syndrome; Quenched activity-based probes; KLK7; Phosphonates; Καλλικρεΐνη 7; Ιχνηθέτες ενεργότητας; Θεραποδιαγνωστικά; Αναστολείς σερινοπρωτεασών; Ατοπική δερματίτιδα; Σύνδρομο Netherton

The generation of a novel activity-based probe (ABP) and inhibitor specific for kallikrein 7 (KLK7) and validation of its therapeutic effects in vivo is described here. KLK7 is a protease with well-established functions in skin inflammation and overdesquamation and in cancer. ABPs, on the other hand...