Nanoparticles and thin films for controlled drug release

• Κύριος συγγραφέας: Ιωάννου, Παναγιώτης
• Άλλοι συγγραφείς: Ioannou, Panagiotis
• Γλώσσα: English
• Έκδοση: 2022
• Θέματα: Drug release; PLGA; Porous silicon; Silicone-like thin films; Anticancer; Drug encapsulation; Αποδέσμευση φαρμάκων; Πορώδες πυρίτιο

Drug release rate control is crucial for many biomedical and especially controlled delivery applications. Poly(Lactic-co-clycolic acid)-(PLGA) and Porous Silicon are highly promising nanotechnology platforms for controlled release and delivery of drugs, displaying several benefits such as bio- and hemocompatibility, biodegrability, form-versatility, multifarious surface chemistry and high drug loading efficiency. Silicone-like thin films, with possible bio-inert behavior, hemocompatibility, water vapor and small molecule permeability can be excellent candidates as diffusion barrier materials for the controlled release of small molecule drugs. This thesis discusses the fabrication of biodegradable polymer microcapsules, nanoparticles and inorganic porous matrices based on PLGA and porous Silicon respectively. Encapsulation and sustainable-prolonged release of both hydrophilic and hydrophobic model drugs, Indomethacin (Anti-inflammatory) and Epirubicin Hydrochloride (Anticancer), from polymer nanoparticles, microcapsules and inorganic porous matrixes are furthermore analyzed. Additionally, atmospheric plasma processing is introduced as a viable approach on rapid, single-step oxidation-stabilization approach for porous Si enabling thus, the hydrophilic drug encapsulation. Finally, atmospheric pressure plasma assisted deposition of Siloxane vapors is proposed, as a solvent-less coating approach, for the preparation of drug permeable thin films on drug loaded matrixes, inhibiting the adverse burst release, which is a common problem on porous systems.