DNA replication deregulation and response pathways following induced genotoxic stress in Schizosaccharomyces pombe

• Main Author: Κασελίμη, Ειρήνη
• Other Authors: Κaselimi, Eirini
• Language: English
• Published: 2022
• Subjects: Genome instability; DNA rereplication; Ribosomal DNA (rDNA); Nucleolus; Schizosaccharomyces pombe; Cdc18/CDC6; DNA replication; Licensing; Γενωμική αστάθεια; Ριβοσωματικό DNA; Επαναντιγραφή του DNA; Πυρηνίσκος; Σχιζοσακχαρομύκητας; Αντιγραφή του DNA; Αδειοδότηση

Eukaryotic sizable genomes start their replication by simultaneous activation of multiple, dispersed origins, which fire stochastically during the S phase. Initiation of DNA replication from each origin is a two-step process, which involves loading of the MCM replicative helicases in an inactive sta...