Delineation of the toxicity of tacrine and its derivatives to the 3D primary human hepatocyte spheroid model

• Main Author: Σισμάνογλου, Δέσποινα-Χριστίνα
• Other Authors: Sismanoglou, Despoina-Christina
• Language: English
• Published: 2022
• Subjects: Tacrine; Hepatotoxicity; Primary human hepatocytes; Τακρίνη; Ηπατοτοξικότητα; Πρωτογενή ανθρώπινα ηπατοκύτταρα

Neurodegenerative disorders constitute a major health problem, with the Alzheimer’s disease being the most common one affecting millions of people worldwide. Tacrine, an inhibitor of the enzyme acetylcholinesterase, entered the market in 1993 and was used with the scope to alleviate the symptoms. De...