Study of structural interaction and molecular dynamics of FOXO transcription factors with molecules of antioncogenic gene p53

• Main Author: Τσούκας, Ευάγγελος
• Other Authors: Tsoukas, Evangelos
• Language: English
• Published: 2023
• Subjects: p53; FOXO4; Structural interaction; Molecular dynamics; Proteins interface; Senolytics; p21 transcription; Δομική αλληλεπίδραση; Μοριακή δυναμική; Διεπιφάνεια πρωτεϊνών; Σενολυτικά μόρια; Μεταγραφή του γονιδίου p21

The transcription factors of FOXO family and the tumor suppressing proteins of p53 have been put under the microscope of pharmaceutical research, since they are involved in the regulation of several signaling pathways related to the DNA repair, the cell cycle arrest and the activation of apoptosis....