Identification of synthetic lethal interactions with DNA replication licensing aberrations

• Main Author: Badra Fajardo, Nibal
• Language: English
• Published: 2023
• Subjects: DNA replication; DNA licensing; Replication stress; DNA damage; Cell cycle; Αντιγραφή του DNA; Βλάβη του DNA; Κυτταρικός κύκλος

Precise and complete genome duplication is critical for a dividing somatic cell to ensure the inheritance of an accurate copy of parental DNA by the offspring. However, multiple DNA barriers commonly arise and disrupt the regular progression of replisomes along replication, posing a threat to timely...