| Περίληψη: | Liver cancer is the sixth most usual form of cancer in the world and remains the third leading cause
of death. The most effective treatment method is surgery.
Radioembolization with 90Y microspheres is a modern form of treatment that combines elements of
brachytherapy and embolization for the treatment of liver cancer. Although it has no
contraindications as a treatment method, it is at the center of attention of medical research due to
its therapeutic effectiveness.
The treatment is based on dosimetric models which are in clinical application. However, the
distribution of microspheres is wrongly assumed to be homogeneous. Through the biodistribution of
the surrogate 99mTc-MAA, which is available from the imaging protocol of radioembolization. There
are significant discrepancies in clinical indications in the distribution between 99mTc-MAA and 90Y
microspheres, probably due to the morphological difference such as the size of the beads and the
number of particles, in the way of their administration and due to imaging limitations, such as
imaging noise.
This thesis aims to improve the estimation of the therapeutic dose deposited by 90Y microspheres
during radioembolization of the liver to develop personalized dosimetry based on Monte Carlo (MC)
simulations.
The 3D model developed was based on the use of Dose Voxel Kernels (DVKs) and was tested on data
from two patients (the first for post-treatment 90Y PET/CT scans and the second for pre-treatment
99mTc-MAA SPECT/CT scans). The comparison results against direct MC simulations. The results of
comparing the measured absorbed dose using DVKs and the direct MC simulation showed a small
difference of the order of 2% for the liver and 4%-7% for the water
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