Study of the effects of various parameters in personalized internal dosimetry for patients undergoing therapies using Lu-177

• Κύριος συγγραφέας: Αθανασλέρη, Θεοδώρα
• Άλλοι συγγραφείς: Athanasleri, Theodora
• Γλώσσα: English
• Έκδοση: 2023
• Θέματα: Δοσιμετρία; Λουτέσιο-177; Πυρηνική ιατρική; Dosimetry; Lu-177; Nuclear medicine

Neuroendocrine tumors (NETs) are a type of cancer that arises from neuroendocrine cells typically occurring in the gastrointestinal tract (approximately 5 cases per 100,000) but can also rarely be found in the bronchopulmonary system and other regions. Prostate cancer, on the other hand, is one of the most common cancers in males. NETs and Prostate cancer are types of cancer that can be treated with 177Lu-DOTA-TATE and 177Lu-PSMA radiopharmaceuticals respectively. The installation of the PLANET® Onco Dose software by Dosisoft at the Nuclear Medicine Department of "Theageneio" Cancer Hospital in Thessaloniki is a useful tool for internal dosimetry calculation. After the administration of the radiopharmaceuticals, patients undergo four consecutive SPECT/CT scans, called time points. The four time points are then reconstructed and sent to the software for processing and calculation of the absorbed dose of the lesions and/or organs at risk. The present study examines two parameters that could potentially lead to more accurate results in the calculation of absorbed doses in these patients.