Electrophysiological study of brain hypoxia

• Κύριος συγγραφέας: Τσαρούχας, Νικόλαος
• Άλλοι συγγραφείς: Μπεζεριάνος, Αναστάσιος
• Μορφή: Thesis
• Γλώσσα: English
• Έκδοση: 2011
• Θέματα: Biomedical neuroengineering tools (Biotechnologies - Neuroinformatics); Pathophysiology of brain hypoxia & hypobaric hypoxia; Electrophysiology of ultrarapid visuocognitive brain responses; Multiresolution time-frequency analysis & continuous wavelet transform; Evoked potentials – evoked/phase-locked & induced/total oscillations; Phase-coherence factor of oscillations across single-trials; Statistical parametric time-frequency map analysis; Generalized method of analysis of variance; Εργαλεία βιοϊατρικής νευρομηχανικής (Βιοτεχνολογίες - Νευροπληροφορική); Παθοφυσιολογία της εγκεφαλικής υποξίας & υποβαρικής υποξίας; Ηλεκτροφυσιολογία των υπερταχείων οπτικογνωστικών αποκρίσεων του εγκεφάλου; Πολυφασματική ανάλυση χρόνου-συχνότητας & συνεχής μετασχηματισμός του κυματίου; Προκλητά δυναμικά – προκλητές/φασικά-κλειδωμένες & επαγόμενες/ολικές ταλαντώσεις; Παράγοντας φασικής συνάφειας ταλαντώσεων μεταξύ μοναδιαίων καταγραφών; Στατιστική παραμετρική ανάλυση χρονοφασματικών χαρτών; Γενικευμένη μέθοδος ανάλυσης των διακυμάνσεων; 616.81

The current research work aims at the development of Biomedical Neuroengineering tools (Biotechnologies) for the in-depth functional study, rapid diagnosis, continuous monitoring and well-timed management of acute and chronic brain disorders, of individuals that are subjected to or suffer from any kind of systemic hypoxaemia or more localized brain hypoxia; as well as the functional assessment and continuous control of adaptability during the training of “altinauts” and generally of individuals that practice activities and function within environments of increased visual-cognitive-motor response demands (a type of brain “stress test”). For this purpose, we subject the entire visuocognitive system, from the elementary sensory to the most complex cognitive level, to an experimental test of categorical discrimination of complex visuocognitive stimuli, following ultra-rapid visual stimulation that leads to a motor response upon categorization of targets (images of animals elicit productive responses) and to its suppression upon categorization of nontargets (images of nonanimals elicit inhibitory responses). The oscillatory electro-physiological responses that are concurrently recorded at the occipital-temporal-parietal brain areas are analyzed in the time-domain (<20Hz) and in the joint time-frequency domain broadband (1-60Hz) with the Continuous Wavelet Transform that optimizes the multiresolution analysis of the high frequency (≥20Hz) γ-band oscillatory activity. This visuocognitive categorization test takes place in normoxaemic as well as hypoxaemic conditions (monitored reduction in the blood oxygen saturation from ≥97% to around 80% under conditions of hypobaric hypoxia within a hypobaric chamber), in order to assess electrophysiological markers that can detect and capture in the most sensitive and dynamic way even so transient, short-living and rather mild changes in brain function. The statistical parametric analysis of the time-frequency maps and the generalized, statistically safer, method of analysis of variance have established as the most sensitive and reliable the following markers: the major deflections of the evoked potentials, the phase-coherence factor of the oscillations across single-trials and the elicited energy of the evoked/phase-locked and the induced/total oscillatory activity. These electrophysiological markers in conjunction with psychometric tests allow for the investigation of the stages/levels of the decline as well as of the compensatory reserves in the visual-perceptive and cognitive-mental brain functions in order to determine the functional sensitivity thresholds of different brain functions to hypoxia. They open up the way for the functional characterization, the diagnosis and monitoring of brain insults or other acute and chronic pathological brain conditions.